Nylon ties that support the main wiring harness to the chassis could wear and break due to excessive vibration. Thus, wiring harness could fall on engine components and short circuit.
Electrical system
Ford E350 Electrical problems by year
0 complaints filed with NHTSA about the Ford E350's electrical system. Dead batteries, warning lights, wiring, alternators, infotainment and electronic module failures.
Source: U.S. National Highway Traffic Safety Administration (NHTSA) complaints and recalls, checked daily. Complaints are owners' own reports and are not verified. How we use the data